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Ústav biochemie a experimentální onkologie

 

1. lékařská fakulta Univerzity Karlovy v Praze

U Nemocnice 5

128 53 Praha 2

Česká Republika

 

 

 

www.lf1.cuni.cz/lbnb

Tel/Fax:00420 224 965 826

E-mail:aleksi@cesnet.cz

Publikační činnost

Monografie

Glioma Cell Biology. Aleksi ŠEDO and Rolf MENTLEIN (eds.). Springer, 2014. ISBN 978-3-7091-1430-8.

 

Doporučené postupy v neuroonkologii v rámci edice Doporučených postupů 5 (Guidelines in Neurooncology for Czech Republic). Kolektiv autorů. Ambit Media, 2013. ISBN 978-80-905474-4. In Czech.

 

Kapitoly v monografiích

BUŠEK, Petr, Martin PŘEVOROVSKÝ, Evžen KŘEPELA and Aleksi ŠEDO. Glioma-Associated Proteases. In: ŠEDO, Aleksi and Rolf MENTLEIN (eds.). Glioma Cell Biology. Springer, 2014, pp. 317–395. ISBN: 978-3-7091-1430-8 (print), 978-3-7091-1431-5 (online).

 

BUŠEK, Petr and Aleksi ŠEDO. Dipeptidyl Peptidase-IV and Related Proteases in Brain Tumors. In: LICHTOR, Terry (ed.). Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications. InTech, 2013. ISBN 978-953-51-0989-1.

 

ŠKRHA, Jan, Tomáš ŠTULC and Aleksi ŠEDO. Inhibice dipeptidylpeptidázy 4 a její vedlejší projevy. In: Diabetes mellitus 2. typu - léčba hyperglykémie, dyslipidémie, hypertenze. 1. vyd. Semily: Geum, 2011, pp. 180–185. ISBN 978-80-86256-78-8. In Czech.

 

ŠIMÁNEK, Vilím, Radim VESPALEC, Aleksi ŠEDO, Jitka ULRYCHOVÁ and Jaroslav VIČAR. Quaternary Benzo/c/phenantridine alkaloids – biological activities. Intracellular targets of their action and application in human and veterinary medicine. In: SCHNEIDER, M. P. (ed.). Chemical Probes in Biology. Kluwer Academic Publishiers, 2003, pp. 245–254.

 

ŠEDO, Aleksi, Radek MALÍK and Evžen KŘEPELA. Dipeptidyl peptidase IV and the differentiation of C6 rat glioma cells. In: HOPSU-HAVU, V. K., M. JARVINEN and H. KIRSCHKE. Proteolysis in Cell Functions. Amsterdam – Berlin – Oxford – Tokyo – Washington, DC: IOS Press, 1997, pp. 423–430.

 

ROVERO, Paolo, Stefano PEGORARO, Aleksi ŠEDO and Roberto REVOLTELLA. A new endothelin c terminal analogue, IBDP 064, antagonizes endothelin-3-induced rat glioma cell proliferation. In: CARPI, A., A. SAGRIPANTI and B. GRASSI. Advances in management of malignances. Cosenza, Italy: Editoriale Bios, 1993, pp. 19–22.

 

Články

 

ŠROMOVÁ, Lucie, Petr BUŠEK, Liliana ŠEDOVÁ, Eva BALÁŽIOVÁ and Aleksi ŠEDO Intraindividual changes of dipeptidyl peptidase-IV in peripheral blood of patients

with rheumatoid arthritis are associated with the disease activity. BMC Musculoskeletal Disorders 2015, vol. 16, pp. 244 - 250.

 

TRYLČOVÁ, Jana, Petr BUŠEK, Karel SMETANA Jr, Eva BALAŽIOVÁ, Barbora DVOŘÁNKOVÁ, Alžběta MIFKOVÁ, Aleksi ŠEDO. Effect of cancer-associated fibroblasts on the migration of glioma cells in vitro. Tumour Biol. 2015, vol. 36, pp. 5873–5879.

 

BUŠEK, Petr, Petr HRABAL, Přemysl FRIČ and Aleksi ŠEDO. Co-expression of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans islets. Histochemistry and Cell Biology. 2014, vol. 143, pp. 497–504.

 

BUŠEK, Petr, Jarmila STREMEŇOVÁ, Lucie ŠROMOVÁ, Marek HILŠER, Eva BALÁŽIOVÁ, David KOSEK, Jana TRYLČOVÁ, Hynek STRNAD, Evžen KŘEPELA and Aleksi ŠEDO. Dipeptidyl peptidase-IV inhibits glioma cell growth independent of its enzymatic activity. International Journal of Biochemistry & Cell Biology. 2012, vol. 44(5), pp. 738–747.

 

BALÁŽIOVÁ, Eva, Petr BUŠEK, Jarmila STREMEŇOVÁ, Lucie ŠROMOVÁ, Evžen KŘEPELA, Libuše LIZCOVÁ and Aleksi ŠEDO. Coupled expression of dipeptidyl peptidase-IV and fibroblast activation protein-α in transformed astrocytic cells. Molecular and Cellular Biochemistry. 2011, vol. 354(1-2), pp. 283–289.

 

ŠROMOVÁ, Lucie, Helena MAREČKOVÁ, Liliana ŠEDOVÁ, Eva BALÁŽIOVÁ and Aleksi ŠEDO. Dipeptidyl peptidase-IV in synovial fluid and in synovial fluid mononuclear cells of patients with rheumatoid arthritis. Clinica Chimica Acta. 2010, vol. 411(15-16), pp. 1003–1164.

 

ŠTULC, Tomáš and Aleksi ŠEDO. Inhibition of multifunctional dipeptidyl peptidase-IV: Is there a risk of oncological and immunological adverse effects? Diabetes Research and Clinical Practice. 2010, vol. 88(2), pp. 125–131.

 

STREMEŇOVÁ Jarmila, Vladislav MAREŠ, Věra LISÁ, Marek HILŠER, Evžen KŘEPELA, Zdislava VANÍČKOVÁ, Martin SYRŮČEK, Oldřich ŠOULA and Aleksi ŠEDO. Expression of dipeptidyl peptidase-IV activity and/or structure homologs in human meningiomas. International Journal of Oncology. 2010, VOL. 36(2), pp. 351–358.

 

ŠEDO, Aleksi, Jarmila STREMEŇOVÁ, Petr BUŠEK and Jonathan DUKE-COHAN. Dipeptidyl peptidase-IV and related molecules: markers of malignancy? Expert Opinion on Medical Diagnostics. 2008, vol. 2(6), pp. 677–689.

 

BUŠEK, Petr, Jarmila STREMEŇOVÁ, Evžen KŘEPELA and Aleksi ŠEDO. Modulation of substance P signaling by dipeptidyl peptidase-IV enzymatic activity in human glioma cell lines. Physiological Research. 2008, vol. 57(3), pp. 443–449.

 

BUŠEK, Petr, Jarmila STREMEŇOVÁ and Aleksi ŠEDO. Dipeptidyl peptidase-IV enzymatic activity bearing molecules in human brain tumors – good or evil? Frontiers in Bioscience. 2008, vol. 13, pp. 2319–2326.

 

STREMEŇOVÁ Jarmila, Evžen KŘEPELA, Vladislav MAREŠ, Julie TRIM, Vladimír DBALÝ, Jan MAREK, Zdislava VANÍČKOVÁ, Věra LISÁ, Carmen YEA and Aleksi ŠEDO. Expression and enzymatic activity of dipeptidyl peptidase-IV in human astrocytic tumours are associated with tumour grade. International Journal of Oncology. 2007, vol. 31(4), pp. 785–792.

 

BUŠEK, Petr, Evžen KŘEPELA, Vladislav MAREŠ, Květoslava VLAŠICOVÁ, Jan ŠEVČÍK and Aleksi ŠEDO. Expression and function of dipeptidyl peptidase IV and related enzymes in cancer. Advances in Experimental Medicine and Biology. 2006, vol. 575, pp. 55–62.

 

BALÁŽIOVÁ, Eva, Liliana ŠEDOVÁ, Vladislav MAREŠ, Květoslava VLAŠICOVÁ, Jan ŠEVČÍK and Aleksi ŠEDO. Dipeptidyl Peptidase-IV Activity and/or Structure Homologs (DASH): Contributing Factors in the Pathogenesis of Rheumatic Diseases? Advances in Experimental Medicine and Biology. 2006, vol. 575, pp. 169–74.

 

ŠEDO, Aleksi, Eva BALÁŽIOVÁ, Liliana ŠEDOVÁ and Jonathan DUKE-COHAN. Dipeptidyl peptidase-IV activity and/or structure homologues (DASH): Contributing factors in the pathogenesis of rheumatoid arthritis? Arthritis Research & Therapy. 2005, vol. 7(6), pp. 253–269.

 

MAREŠ, Vladislav, Radek MALÍK, Věra LISÁ and Aleksi ŠEDO. Up-regulation of gamma-glutamyltransferase (GGT) activity in growth modulated astrocytic C6 glial cells in culture. Molecular Brain Research. 2005, vol. 136(1-2), pp. 75-80.

 

BUŠEK, Petr, Radek MALÍK and Aleksi ŠEDO. Dipeptidyl peptidase IV activity and/or structure homologues (DASH) and their substrates in cancer. International Journal of Biochemistry & Cell Biology. 2004, vol. 36, pp. 408–421.

 

ŠEDO, Aleksi, Petr BUŠEK et al. 'Dipeptidyl peptidase-IV activity and/or structure homologs' (DASH) in growth-modulated glioma cell lines. Biological Chemistry. 2004, vol. 385, pp. 557–559.

 

CHOVANEC, Martin, Karel SMETANA, ..... Aleksi ŠEDO et al. Detection of cell type and marker specificity of nuclear binding sites for anionic carbohydrate ligands. Biotechnic & Histochemistry. 2004, vol. 79, pp. 139–150.

 

ŠEDO, Aleksi, Radek MALÍK et al. Quaternary benzo[c]phenanthridine alkaloids as inhibitors of dipeptidyl peptidase IV-like activity bearing enzymes in human blood plasma and glioma cell lines. Physiological Research. 2003, vol. 52, pp. 367–372.

 

MAREŠ, Vladislav, ..... and Aleksi ŠEDO. Cisplatin induced gamma-glutamyltransferase up-regulation, hypertrophy and differentiation in astrocytic glioma cells in culture. Histology and Histopathology. 2003, vol. 18, pp. 687–693.

 

MALÍK, Radek, Petr BUŠEK, Vladislav MAREŠ, Jan ŠEVČÍK, Zdeněk KLEIBL and Aleksi ŠEDO. Dipeptidyl peptidase-IV activity and/or structure homologues (DASH) in transformed neuroectodermal cells. Advances in Experimental Medicine and Biology. 2003, vol. 524, pp. 95–102.

 

MALÍK, Radek, Květa VLAŠICOVÁ and Aleksi ŠEDO. Functional cross-talk of Ca2+-mobilizing endothelin receptors in C6 glioma cells. Physiological Research. 2002, vol. 51, pp. 73–78.

 

ŠEDO, Aleksi, Květa VLAŠICOVÁ, Pavel BARTÁK et al. Quaternary benzo[c]phenanthridine alkaloids as inhibitors of aminopeptidase N and dipeptidyl peptidase IV. Phytotherapy Research. 2002, vol. 16, pp. 84–87.

 

ŠEDO, Aleksi, Radek MALÍK, Karel DRBAL et al. Dipeptidyl Peptidase IV in Two Human Glioma Cell Lines of Different Phenotype and Proliferation Properties. European Journal of Histochemistry. 2001, vol. 45, pp. 57–63.

 

ŠEDO, Aleksi and Radek MALÍK. Dipeptidyl peptidase IV-like molecules: homologous proteins or homologous activities? Biochimica et Biophysica Acta. 2001, vol. 1550, pp.107–116.

 

MALÍK, Radek, Zdeněk KLEIBL, Petr POHLREICH, ..... and Aleksi ŠEDO. Diversity of Mahogany/Attractin expression and its dipeptidyl peptidase IV enzyme activity in glioma cells. Biochemical and Biophysical Research Communications. 2001, vol. 284, pp. 289–294.

 

ULRICHOVÁ, Jitka, Zdeněk DVOŘÁK, ..... Aleksi ŠEDO et al. Cytotoxicity of natural compounds in hepatocyte cell culture models – The case of quaternary benzo[c]phenanthridine alkaloids. Toxicology Letters. 2001, vol. 125, pp. 125–132.

 

MALÍK, Radek, Květa VLAŠICOVÁ, Libuše KADLECOVÁ and Aleksi ŠEDO. Heterogeneity of Dipeptidyl Peptidase IV from Rat Glioma Cells. Neoplasma. 2000, vol. 47, pp. 96–99.

 

ŠEDO, Aleksi, Radek MALÍK, Květa VLAŠICOVÁ et al. Calcium-mediated endothelin signaling in C6 rat glioma cell line. Neuropeptides. 1999, vol. 33. pp. 13–17.

 

ŠEDO, Aleksi, Radek MALÍK and Evžen KŘEPELA. Dipeptidyl peptidase IV in C6 rat glioma cell line differentiation. Biological Chemistry. 1998, vol. 379, pp. 39–44.

 

ŠEDO, Aleksi and Zdislava VANÍČKOVÁ. Endothelins as cell growth regulators. Folia Biologica. 1996, vol. 45, pp. 79–82.

 

ŠEDO, Aleksi, Václav MANDYS, and Evžen KŘEPELA. Cell membrane-bound proteases: not "only" proteolysis. Physiological Research. 1996, vol. 45, pp. 169–176.

 

ŠEDO, Aleksi, Radek MALÍK, Miloš VOTRUBA et al. Serum dipeptidyl peptidase IV activities in Czernobyl zone inhabitants exposed to power-station catastrophe. European journal of clinical chemistry and clinical biochemistry. 1996, vol. 34, pp. 447–448.

 

ŠEDO, Aleksi, Joan Van WEYNBERGH, Danny RAOUILOARD, Brigite BAUVOIS. Synergistic effect of prolactin on IFN-gamma mediated-growth arrest in human monocytic cells: correlation with the up-regulation of IFN-gamma receptor expression. Immunology Letters. 1996, vol. 53, pp. 125–130.

 

ŠEDO, Aleksi, Stefano PEORARO, Paolo ROVERO et al. A new endothelin C-terminal analogue IBDP 064 antagonizes endothelin-3-induced cell proliferation. Folia Biologica. 1995, vol. 41, pp. 97–105.

 

ŠEDO, Aleksi and Roberto REVOLTELLA. Detection of dipeptidyl peptidase IV activity in glioma C6 and neuroblastoma SK-N-SH cell lines. Biochemistry and Cell Biology. 1995, vol. 73, pp. 113–115.

 

ŠEDO, Aleksi and Jiří KRAML. Dipeptidyl peptidase IV in cell proliferation and differentiation. Sborník lékařský. 1994, vol. 95, pp. 295–298.

 

ŠEDO, Aleksi, Paolo ROVERO, Roberto REVOLTELLA et al. BQ-123 inhibits both endothelin 1 and endothelin 3 mediated C6 rat glioma cell proliferation suggesting an atypical endothelin receptor. Journal of biological regulators and homeostatic agents. 1993, vol. 7, pp. 95–97.

 

KASAFÍREK, Evžen, Miroslav RYBÁK, Ivan KREJČÍ, ..... and Aleksi ŠEDO. Two-step enzyme generation of spirocyclic dipeptides from their linear peptide precursors. Life Sciences. 1992, vol. 50, pp. 187–193.

 

ŠEDO, Aleksi, Evžen KŘEPELA, Evžen KASAFÍREK et al. Dipeptidyl peptidase IV in human lung and spinocellular lung cancer. Physiological Research. 1991, vol. 40, pp. 359–362.

 

ŠEDO, Aleksi, Evžen KŘEPELA and Evžen KASAFÍREK. Dipeptidyl peptidase IV, prolyl endopeptidase and cathepsin B activities in primary human lung tumors and lung parenchyma. Journal of Cancer Research and Clinical Oncology. 1991, vol. 117, pp. 249–253.

 

PROCHÁZKA, Jan, Evžen KŘEPELA, Aleksi ŠEDO et al. Aminopeptidases and angiotensin I-converting enzyme activities in primary human lung tumors and lung parenchyma. Neoplasma. 1991, vol. 38, pp. 501–508.

 

KŘEPELA, Evžen and Aleksi ŠEDO. Cytocentrifugační sedimentátor. Czechoslovak Patent Gazette. 1990, vol. 5, p. 210. In Czech.

 

ŠEDO, Aleksi and Miloslav ADAMEC. A Pascal Program for the Computing of DNA Concentration in Cellular Homogenates. Computer Methods and Programs in Biomedicine. 1990, vol. 33, pp. 189–190.

 

ŠEDO, Aleksi and Evžen KŘEPELA. Dipeptidylpeptidasa IV v lymfocytech a lymfatických orgánech člověka. Československá fyziologie. 1989, vol. 34, pp. 69–84. In Czech.

 

ŠEDO, Aleksi, Evžen KŘEPELA and Evžen KASAFÍREK. A kinetic fluorometric assay of dipeptidyl peptidase IV in viable human blood mononuclear cells. Biochimie. Paris. 1989, vol. 71, pp. 757–761.

 

ŠEDO, Aleksi and Liliana LIBEROFF. Změny aktivity dipeptidylpeptidasy IV v séru nemocných s karcinomem děložního hrdla před a po léčbě. Československá gynekologie. 1986, vol. 51, pp. 772–775. In Czech.

 

ŠEDO, Aleksi, Karel HÁTLE and Pavel ŠTOLBA. Změny aktivity dipeptidylpeptidasy IV v lidském séru při některých onemocněních štítné žlázy. Časopis lékařů českých. 1985, vol. 124, pp. 1579–1581. In Czech.

 

Patenty

 

KASAFÍREK, Evžen, Jan PIHERA and Aleksi ŠEDO. Oligopeptidic inhibitors of elastase. Czech Republic. Patent 285 911. 1999.

 

KASAFÍREK, Evžen, Jan PIHERA and Aleksi ŠEDO. Oligopeptidic elastase inhibitors. PCT patent PCT/CZ98/00019. 1998.

 

KASAFÍREK, Evžen, Antonín ŠTURC, Jiří MOURAL, ..... and Aleksi ŠEDO. Peptidic precursors of biologically active cyclic dipeptides. Czech Republic. Patent 280 726. 1996.

 

KŘEPELA, Evžen and Aleksi ŠEDO. Centrifugační cytosedimentátor. Autorské osvědčení 272 510. 1990.